In the Kirchdoerfer lab, we study a family of viruses called Coronaviruses. This diverse family of viruses includes human pathogens such as SARS-CoV-1, SARS-CoV-2 (COVID-19), and MERS-CoV in addition to a number of important animal pathogens. We use a combination of biochemistry and structural biology techniques to produce high-resolution views of coronavirus proteins, gaining insights into how these molecular machines accomplish tasks for the virus during the infection cycle. In particular, we focus on how coronaviruses enter cells and how they replicate their genomes once they get inside. To accomplish these tasks, coronaviruses produce a suite of proteins. Because some of the viruses that we study are human pathogens, many projects in the lab circumvent working with live virus entirely and instead focus on individual viral proteins produced using recombinant technologies in specialized systems. These proteins are then used in biochemical assays or imaged using an electron microscope to determine their function and structure. The long-term goals of these studies is the development of potential antiviral drugs and vaccine immunogens.